Crucial Philosophical Implications of Neuroplasticity


  • Lucas Peluffo Independent Researcher, San Luis 2571, 9b, Ciudad Autónoma de Buenos Aires, 1056, República Argentina



This article briefly reviews neuroplasticity's basic terms and mechanisms and then emphasizes three crucial philosophical implications. (1) Considering the relationship of epistemology with the brain, the main organ of human intelligence is now proven to have the capacity to reorganize itself structurally. (2) Neuroplasticity has startled metaphysicians by embodying a mechanism that appears to challenge any strict—non-interactive—interpretations of the controversial term mind-body dualism. (3) Within morality and ethics, many neuroscientific studies performed on Buddhist meditators of Indic meditative traditions have linked positive neuroplasticity with empathy, compassion, and loving-kindness, indicating that these qualities can be developed consciously and suggesting that they may be intrinsic to human beings.


neurophilosophy, neuroplasticity, mind-body dualism, evolution, empathy, compassion, loving-kindness


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Author Biography

Lucas Peluffo, Independent Researcher, San Luis 2571, 9b, Ciudad Autónoma de Buenos Aires, 1056, República Argentina

Independent Researcher, San Luis 2571, 9b, Ciudad Autónoma de Buenos Aires, 1056, República Argentina


Acharya S & Shukla S. Mirror neurons: Enigma of the metaphysical modular brain. J Nat Sc Biol Med 2012; 3(2):118-24.

Askenasy J & Lehmann J. Consciousness, brain, neuroplasticity. Front Psychol 2013; 10(4):412.

Brans RG, Kahn RS, Schnack HG, van Baal GC, Posthuma D, van Haren NE, Lepage C, Lerch JP, Collins DL, Evans AC, Boomsma DI & Hulshoff P. Brain plasticity and intellectual ability are influenced by shared genes. J Neurosci 2010; 30(16):5519-24.

Cucu, A. Turning the Tables: How Neuroscience Supports Interactive Dualism. J of Conscious Stud 2022; 9: 219-39.

Doidge, N. The brain’s way of healing: Remarkable discoveries and recoveries from the frontiers of neuroplasticity. New York: Penguin Books, 2016.

Förster, K & Kanske, P. Exploiting the plasticity of compassion to improve psychotherapy. Curr Opin Behav Sci 2021; 39: 64-71.

García de Frutos, H. Neurociencias y psicoanálisis: consideraciones epistemológicas para una dialéctica posible sobre la subjetividad [Neurosciences and psychoanalisis: Epistemological considerations toward a possible dialectic about subjectivity]. Rev Asoc Esp de Neuropsiq 2011; 31:4.

Gholami K, Alikhani M & Tirri K. Empirical model of teachers' neuroplasticity knowledge, mindset, and epistemological belief system. Front Psychol 2022; 13.

Goleman, D & Davidson RJ. Altered traits: Science reveals how meditation changes your mind, brain and body. New York: Penguin Random House, 2017.

Keshavan, MS, Mehta, UM, Padmanabhan, JL & Shah, JL. Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions. Dev Psychopathol 2015; 27(2): 615–635.

Kolstad A. From the Machine Paradigm to Brain Plasticity and How Culture Overrules Biology in Humans. Psychology 2012: 3(9): 691-697.

Kormas P, Moutzouri A and Protopapadakis ED. Implications of Neuroplasticity to the Philosophical Debate of Free Will and Determinism. In: Vlamos, P, Kotsireas, IS & Tarnanas, I. (eds) Handbook of Computational Neurodegeneration. Springer, Cham. 2023.

Leung M-K, Chan Chetwyn CH, Yin J, Lee C-F, & Lee Tatia MC. Increased gray matter volume in the right angular and posterior parahippocampal gyri in loving-kindness meditators. Soc Cogn Affect Neurosci 2013; 8(1):34-9.

Leung, M-K, Lau, WKW, Chan, CCH, Wong, SSY, Fung, ALC & Lee, TMC Meditation-induced neuroplastic changes in amygdala activity during negative affective processing. Soc Neurosci 2018;13(3):277-288.

Lin, Chien-Te. Rethinking mind-body dualism: A Buddhist take on the mind-body problem. Contemp. Buddhism 2013; 14(2): 239-264.

Loizzo, J, Neale, M & Wolf, EJ. (Eds.) Advances in Contemplative Psychotherapy: Accelerating Healing and Transformation. New York: Routledge, 2017.

Lutz, A, Greischar, LL, Rawlings, NB, Ricard, M & Davidson, RJ. Long-term meditators self-induce high amplitude gamma synchrony during mental practice. Proc Natl Acad Sci U.S.A. 2004; 101(46): 16369-16373.

Mishra J & Gazzaley, A. Cross-species approaches to cognitive neuroplasticity research. NeuroImage 2013; 131:4-12.

Muñoz JM. Neurofilosofía y libre albedrío [Neurophilosophy and free will]. Daimon 2013; 5(9): 57-70.

Orvis J, Albertin CB, Shrestha P, Chen S, Zheng M, Rodriguez CJ, Tallon LJ, Mahurkar A, Zimin AV, Kim M, Liu K, Kandel ER, Fraser CM, Sossin W & Abrams, TW. The evolution of synaptic and cognitive capacity: Insights from the nervous system transcriptome of Aplysia. Proc Natl Acad Sci U.S.A. 2022; 119 (28): 1-11.

Salzberg, S & Thurman, R. Love your enemies: How to break the anger habit and be a whole lot happier. Hay House: Carlsbad, 2013.

Tarlacı S. Implications of Neuroscience for Ancient Traditional Philosophical Questions. Journal of Neurophilosophy 2013; 2(2):195-203.

Trilla Gros I, Panasiti MS & Chakrabarti B. The plasticity of the mirror system: how reward learning modulates cortical motor simulation of others. Neuropsychologia 2015; 70:255-262.

Valk, SL. Structural plasticity of the social brain: Differential change after socio-affective and cognitive mental training. Sci Adv 2017; 3.

Vollmer, L. Change your mind: Neuroplasticity and Buddhist transformation. MAthesis. Washington University in Saint Louis, Department of East Asian Studies, 2010.




How to Cite

Peluffo, L. (2024). Crucial Philosophical Implications of Neuroplasticity. Journal of NeuroPhilosophy, 3(1).